It has long been established by many epidemiological studies that moderate consumption of red wine reduces the risk of cardiovascular disease. The mechanisms behind polyphenol action, however, remained a mystery. A team of research scientists in Angers (Inserm UMR 771-University of Angers research unit “Integrated Neurovascular Biology”) has identified the alpha subtype of the oestrogen receptor as playing a key role in the transduction of wine polyphenols, thus providing an explanation for what has become known as the “French Paradox”. Their results have been published in the journal PloS ONE.
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